The Cape Girardeau Police Department was established by City Ordinance on March 25, 1859.

1904-1905 John Grieb, City Marshall
1905-1911 WillisA. Martin, City Marshall
1911-1913 W.A. Summers, City Marshall
1913 D.A. Nicols, City Marshall
1913-1916 Nathaniel J. Hutson, City Marshall
1916-1918 Arthur S. Whitener, City Marshall
1918-1921 W.J. Segraves, Chief of Police
1921-1922 Nathaniel J. Hutson, Chief of Police
1922-1924 H.F. Wickham, Chief of Police
1924-1925 Arthur S. Whitener, Chief of Police
1925 W.C. Kelpe, Interim Chief of Police
1925-1926 W.W. Billings, Chief of Police
1926-1930 H.F. Wickham, Chief of Police
1930-1934 J.E. Crafton, Chief of Police
1934-1936 Edgar W. Hirsch, Chief of Police
1936-1937 Herbert F. Wickham, Jr., Chief of Police
1937 Paul McNeely, Chief of Police
1937-1938 Charles Schweer, Chief of Police
1938-1940 Edgar W. Hirsch, Chief of Police
1940-1941 Ed Barenkamp, Chief of Police
1946 Marshall F. Morton, Chief of Police
1946-1947 F.L. Schneider, Chief of Police
1947-1948 John Penn, Chief of Police
1948-1952 William A. Mills, Chief of Police
1952 F.L. Schneider, Chief of Police
1952-1953 Irvin Richmond, Chief of Police
1953-1954 Marshall F. Morton, Chief of Police
1954-1955 Kenneth Cruse,Chief of Police
1955-1956 F.L. Schneider, Chief of Police
1956-1964 Percy R. Little, Chief of Police
1964-1974 Irvin E. Beard, Chief of Police
1974 Donald R. Roberts, Interim Chief of Police
1974 W.W. Stover, Interim Chief of Police
1974-1981 Henry H. Gerecke, Chief of Police
1981-1982 Donald R. Roberts,InterimChief of Police
1982-1988 D. Ray Johnson, Chief of Police
1988-1989 Howard H. Boyd, Jr., Interim Chief of Police
1989-1996 Howard H. Boyd, Jr., Chief of Police
1996-1997 Stephen C. Strong, Interim Chief of Police
1997-2001 Richard L. Hetzel, Chief of Police
2001-2005 Stephen C. Strong, Chief of Police
2005-2012 Carl A. Kinnison, Chief of Police
2012-2013
Roger W. Fields, InterimChief of Police
2013-Present
Wes Blair, Chief of Police